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Year Number of Results
2001 1
2004 1
2005 1
2006 3
2007 1
2008 1
2009 3
2010 5
2011 1
2012 5
2013 1
2014 4
2015 1
2024 0

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24 results

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Page 1
Clinging to life: cell to matrix adhesion and cell survival.
Reddig PJ, Juliano RL. Reddig PJ, et al. Cancer Metastasis Rev. 2005 Sep;24(3):425-39. doi: 10.1007/s10555-005-5134-3. Cancer Metastasis Rev. 2005. PMID: 16258730 Review.
Cell to matrix adhesion regulates cellular homeostasis in multiple ways. ...Anchorage independent growth is a critical step in the tumorigenic transformation of cells. Thus, breaching the anoikis barrier disrupts the cell's defenses against transformation …
Cell to matrix adhesion regulates cellular homeostasis in multiple ways. ...Anchorage independent growth is a critical step in the tu …
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation.
Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. Anczuków O, et al. Nat Struct Mol Biol. 2012 Jan 15;19(2):220-8. doi: 10.1038/nsmb.2207. Nat Struct Mol Biol. 2012. PMID: 22245967 Free PMC article.
SRSF1 overexpression promoted alternative splicing of BIM (also known as BCL2L11) and BIN1 to produce isoforms that lack pro-apoptotic functions and contribute to the phenotype. ...
SRSF1 overexpression promoted alternative splicing of BIM (also known as BCL2L11) and BIN1 to produce isoforms that lack pro-apoptoti …
Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: sensitivity and resistance.
Takeuchi S, Yano S. Takeuchi S, et al. Respir Investig. 2014 Nov;52(6):348-56. doi: 10.1016/j.resinv.2014.10.002. Epub 2014 Oct 31. Respir Investig. 2014. PMID: 25453378 Review.
Possible mechanisms of acquired resistance to EGFR-TKI, thus far, include a gatekeeper mutation of EGFR, activation of an alternate pathway, activation of EGFR downstream signals, transformation to small cell lung cancer, and epithelial-mesenchymal transition (EMT). …
Possible mechanisms of acquired resistance to EGFR-TKI, thus far, include a gatekeeper mutation of EGFR, activation of an alternate pathway, …
The expression of SIAH1 is downregulated and associated with Bim and apoptosis in human breast cancer tissues and cells.
Wen YY, Yang ZQ, Song M, Li BL, Yao XH, Chen XL, Zhao J, Lu YY, Zhu JJ, Wang EH. Wen YY, et al. Mol Carcinog. 2010 May;49(5):440-9. doi: 10.1002/mc.20615. Mol Carcinog. 2010. PMID: 20082325
Seven in absentia homolog1 (SIAH1) was reported as a tumor suppressor and played an important role in regulating cell apoptosis. However, its effects on the breast carcinogenesis remain unclear. ...Reverse transcription (RT)-polymerase chain reaction (PCR) and Western blot …
Seven in absentia homolog1 (SIAH1) was reported as a tumor suppressor and played an important role in regulating cell apoptosis. Howe …
A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia.
Zhang LN, Li JY, Xu W. Zhang LN, et al. Cancer Gene Ther. 2013 Jan;20(1):1-7. doi: 10.1038/cgt.2012.84. Epub 2012 Nov 23. Cancer Gene Ther. 2013. PMID: 23175245 Review.
The entire pathogenesis of CLL is not clear now, but defective regulation of apoptosis seems to be more important than uncontrolled cell proliferation in CLL. There are two main pathways of apoptosis: the extrinsic pathway and the intrinsic pathway. It is worth noting that …
The entire pathogenesis of CLL is not clear now, but defective regulation of apoptosis seems to be more important than uncontrolled cell …
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.
Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, Munker R, Volinia S, Boccadoro M, Garzon R, Palumbo A, Aqeilan RI, Croce CM. Pichiorri F, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. doi: 10.1073/pnas.0806202105. Epub 2008 Aug 26. Proc Natl Acad Sci U S A. 2008. PMID: 18728182 Free PMC article.
Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whet …
Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs ( …
Functional and biological analysis of Bcl-xL expression in human osteosarcoma.
Wang ZX, Yang JS, Pan X, Wang JR, Li J, Yin YM, De W. Wang ZX, et al. Bone. 2010 Aug;47(2):445-54. doi: 10.1016/j.bone.2010.05.027. Epub 2010 May 23. Bone. 2010. PMID: 20580954
Bcl-xL, a member of Bcl-2 protein family functioned as dominant regulators of apoptotic cell death, has been reported to play important roles in malignant transformation and tumor development. ...Real-time quantitative RT-PCR and Western blot or immunohistochemistry …
Bcl-xL, a member of Bcl-2 protein family functioned as dominant regulators of apoptotic cell death, has been reported to play importa …
Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.
Higuchi M, Takahashi M, Tanaka Y, Fujii M. Higuchi M, et al. Cancer Med. 2014 Dec;3(6):1605-14. doi: 10.1002/cam4.329. Epub 2014 Aug 30. Cancer Med. 2014. PMID: 25175936 Free PMC article.
Human T-cell leukemia virus type 1 (HTLV-1), an etiological agent of adult T-cell leukemia, immortalizes and transforms primary human T cells in vitro in both an interleukin (IL)-2-dependent and IL-2-independent manner. ...Knockdown of Bim expression in CTLL-2 cells …
Human T-cell leukemia virus type 1 (HTLV-1), an etiological agent of adult T-cell leukemia, immortalizes and transforms primar …
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins.
Scheijen B, Ngo HT, Kang H, Griffin JD. Scheijen B, et al. Oncogene. 2004 Apr 22;23(19):3338-49. doi: 10.1038/sj.onc.1207456. Oncogene. 2004. PMID: 14981546
FLT3-ITD receptors exhibit constitutive tyrosine kinase activity in the absence of FLT3 ligand (FL) binding, and when expressed in cytokine-dependent cell lines and primary hematopoietic cells suppress programmed cell death and increase cell division. ...Thes …
FLT3-ITD receptors exhibit constitutive tyrosine kinase activity in the absence of FLT3 ligand (FL) binding, and when expressed in cytokine- …
Targeting the regulatory machinery of BIM for cancer therapy.
Harada H, Grant S. Harada H, et al. Crit Rev Eukaryot Gene Expr. 2012;22(2):117-29. doi: 10.1615/critreveukargeneexpr.v22.i2.40. Crit Rev Eukaryot Gene Expr. 2012. PMID: 22856430 Free PMC article.
Recent evidence suggests that in addition to its involvement in normal homeostasis, BIM plays a critical role in tumor cell biology, including the regulation of tumorigenesis through activities as a tumor suppressor, tumor metastasis, and tumor cell survival. ...Sig …
Recent evidence suggests that in addition to its involvement in normal homeostasis, BIM plays a critical role in tumor cell biology, …
24 results